Del Mar Photonics - Newsletter Fall 2010 - Newsletter Winter 2010
Photonics West 2011
Presentations by featured Del Mar Photonics' customers.
Inactivation of encephalomyocarditis virus and herpes simplex virus by using
a visible femtosecond laser
Paper 7895-28 of Conference 7895
Date: Wednesday, 26 January 2011
Time: 12:10 PM ?12:30 PM
Author(s): Shaw-Wei D. Tsen, Washington Univ. in St. Louis (United States); Kong-Thon Tsen, Arizona State Univ. (United States)
Recently, a variety of viral systems, including M13 bacteriophage, tobacco mosaic virus (TMV), human papillomavirus (HPV) and human immunodeficiency virus (HIV) have been shown to be inactivated by the irradiation of a near-infrared subpicosecond fiber laser. These experimental results indicated that the inactivation of viruses by an ultrashort pulsed laser might involve disruption of their protein coat through laser-induced excitation of large-amplitude acoustic vibrations. In this work, we report experimental results on the inactivation of both encephalomyocarditis virus (EMCV) and herpes simplex virus (HSV) by using a visible femtosecond laser derived from the second harmonic generation of a cw mode-locked Ti-sapphire laser system. The inactivation of these viral particles has been demonstrated to depend on the laser exposure time as well as laser power density. Possible mechanisms for the inactivation will be discussed.
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