Del Mar Photonics

New Laser Focus Webcast scheduled for Thursday, April 26th, 2007 1:00PM EDT | 17:00 GMT

Ultrafast 2-D Vibrational Echo Experiments with Applications in Chemistry and Biology

Ultrafast 2D-IR vibrational echo experiments are akin to 2D NMR but operate on time scales 6 to 10 orders of magnitude faster than NMR. The method is illustrated with chemical exchange experiments that directly observe solute-solvent complex formation and dissociation, as well as isomerization around a carbon-carbon single bond. Experiments on proteins and enzymes measure structural dynamics and the influence of substrate binding on enzyme dynamics.

Michael D. Fayer, Professor of Chemistry, Stanford University
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Are you a graduate or undergraduate student currently working in Ultrafast 2-D Vibrational Echo experiments?
We have part time job opportunity for you with potential full time employment in the future! Please send us description of your experience in Ultrafast Dynamics research!
Del Mar Photonics team includes industry veterans, bright young researches and engineers as well as strong team of part time and seasonal sales personnel and ready to join our team students and graduated students, currently working with us on a part time basis.

Related Publications

Fayer Group

揢ltrafast Solute-Solvent Complex Chemical Exchange Observed in Real Time: Multidimensional Vibrational Echo Correlation Spectroscopy,?Junrong Zheng, Kyungwon Kwak, John Asbury, Xin Chen, I. Piletic, and M. D. Fayer, Science 309, 1338-1343 (2005). pdf

?span style="COLOR: black">Dynamics of Water Probed with Vibrational Echo Correlation Spectroscopy,?John B. Asbury, Tobias Steinel, Kyungwon Kwak, S. A. Corcelli, C. P. Lawrence, J. L. Skinner, and M. D. Fayer, J. Chem. Phys. 121, 12431-12446 (2004). pdf

揤ibrational Echo Correlation Spectroscopy Probes of Hydrogen Bond Dynamics in Water and Methanol,?John B. Asbury, Tobias Steinel, and M. D. Fayer, J. Lumin. 107, 271-286 (2004). pdf  

揢sing Ultrafast Infrared Multidimensional Correlation Spectroscopy to Aid in Vibrational Spectral Peak Assignments,?John B. Asbury, Tobias Steinel, M. D. Fayer, Chem. Phys. Lett. 381, 139-146 (2003). pdf

Tokmakoff Group


Water Penetration into Protein Secondary Structure Revealed by Hydrogen-Deuterium Exchange Two-Dimensional Infrared Spectroscopy L.P. DeFlores and A. Tokmakoff, J. Am. Chem. Soc., (2006).

Multidimensional infrared spectroscopy of water. I. Vibrational dynamics in two-dimensional IR line shapes J. J Loparo, S. T. Roberts, and A. Tokmakoff, J. Chem. Phys. 125, 194521, (2006).

Multidimensional infrared spectroscopy of water. II. Hydrogen bond switching dynamics J. J Loparo, S. T. Roberts, and A. Tokmakoff, J. Chem. Phys. 125, 194522, (2006).

Characterization of spectral diffusion from two-dimensional line shapes S. T. Roberts, J. J Loparo, and A. Tokmakoff, J.Chem. Phys, 125, 084502 (2006).

Spectral Signatures of Heterogeneous Protein Ensembles Revealed by MD Simulations of 2DIR Spectra Z. Ganim and A. Tokmakoff, Biophysical Journal, 91, 2636-2646 (2006).

The Anharmonic Vibrational Potential and Relaxation Pathways of the Amide I and II Modes of N-Methylacetamide L. P. DeFlores, Z. Ganim, S. F. Ackley, H. S. Chung, and A. Tokmakoff, J. Phys. Chem. B, 110(38), 18973-18980 (2006).

Single-shot two-dimensional spectrometer M. F. DeCamp, and A. Tokmakoff, Opt. Lett., 31, 113-115 (2006).

Visualization and Characterization of the Infrared Active Amide I Vibrations of Proteins H. S. Chung, and A. Tokmakoff, J. Phys. Chem. B, 110, 2888-2898 (2006).


Hydrogen bonds in liquid water are broken only fleetingly J. D. Eaves*, J. J. Loparo*, C. J. Fecko, S. T. Roberts, A. Tokmakoff, and P. L. Geissler, PNAS, 102, 13019-13022 (2005).

Electric Field Fluctuations Drive Vibrational Dephasing in Water J. D. Eaves, A. Tokmakoff, and P. L. Geissler, J. Phys. Chem. A, 109(42), 9424-9436 (2005).

Residual Native Structure in a Thermally Denatured b-Hairpin A. W. Smith, H. S. Chung, Z. Ganim, and A. Tokmakoff, J. of Phys. Chem. B, 109, 17025-17027 (2005).

Upconversion multichannel infrared spectrometer M. F. DeCamp, and A. Tokmakoff, Opt. Lett., 30, 1818-1820 (2005).

Amide I Vibrational Dynamics of N-Methylacetamide in Polar Solvents: The Role of Electrostatic Interactions M. F. DeCamp, L. P. DeFlores, J. M. McCracken, A. Tokmakoff, K. Kwac, and M. Cho, J. of Phys. Chem. B, 109, 11016-11026 (2005).

Conformational changes during the nanosecond-to-millisecond unfolding of ubiquitin. H. Chung, M. Khalil, A. W. Smith, Z. Ganim, and A. Tokmakoff, PNAS, 102, 612-617 (2005).

Local hydrogen bonding dynamics and collective reorganization in water: Ultrafast infrared spectroscopy of HOD/D2O. C.J. Fecko, J. J. Loparo, S. T. Roberts, and A. Tokmakoff, J. Chem. Phys, 122, 054506 (2005).


Reorientational and configurational fluctuations in water observed on the molecule length scales. J. J. Loparo, C.J. Fecko, J.D. Eaves, S. T. Roberts, and A. Tokmakoff, Phys. Rev. B, 70, 180201 (2004).

Nonlinear infrared spectroscopy of protein conformational change during thermal unfolding. H. Chung, M. Khalil and A. Tokmakoff, J. Phys. Chem. B, 108, 15332 (2004).

Two-dimensional infrared spectroscopy of antiparallel b-sheet secondary structure. N. Demirdöven, C. M. Cheatum, H. Chung, M. Khalil, J. Knoester and A. Tokmakoff, J. Am. Chem. Soc., 126, 7981(2004).

Vibrational coherence transfer characterized with Fourier-transform 2D IR spectroscopy. M. Khalil, N. Demirdöven and A. Tokmakoff, J. Chem. Phys, 121, 362 (2004).

Generation of 45 femtosecond pulses at 3 mm with a KNbO3 optical parametric amplifier. C. J. Fecko, J. J. Loparo and A. Tokmakoff, Optics Communications, 241, 521-528 (2004).


Signatures of b-sheet secondary structures in linear and two-dimensional infrared spectroscopy. C. M. Cheatum, A. Tokmakoff, and J. Knoester, J. Chem. Phys., 120, 8201 (2003).

Coherent 2D IR Spectroscopy: Molecular Structure and Dynamics in Solution. M. Khalil, N. Demirdoven, A. Tokmakoff, J. Phys. Chem. A., 107, 5258-5279(2003).

Polarization-selective femtosecond Raman spectroscopy of low-frequency motions in hydrated protein films. J. D. Eaves, C. J. Fecko, A. L. Stevens, P.l Peng and A. Tokmakoff, Chem. Phys. Let., 376 (2003)

Ultrafast Hydrogen-Bond Dynamics in the Infrared Spectroscopy of Water. C. J. Fecko, J. D. Eaves, J. J. Loparo, A. Tokmakoff, P. L. Geissler, Science, 301, 1698-1702 (2003)

Obtaining absorptive line shapes in two-dimensional infrared vibrational correlation spectra. M. Khalil, N. Demirdoven, A. Tokmakoff, Phys. Rev. Lett., 90 (2003).


Correlated vibrational dynamics revealed by two-dimensional infrared spectroscopy. N. Demirdoven, M. Khalil, A. Tokmakoff, Phys. Rev. Lett., 89 (2002).

Isotropic and anisotropic Raman scattering from molecular liquids measured by spatially masked optical Kerr effect spectroscopy. C. J. Fecko, J. D. Eaves, and A. Tokmakoff, J. Chem. Phys., 117, 1139 (2002).

Dispersion compensation with optical materials for compression of intense sub-100-fs mid-infrared pulses. N. Demirdoven, M. Khalil, O. Golonzka, and A. Tokmakoff, Opt. Let., 27, 433 (2002).


Coupling and orientation between anharmonic vibrations characterized with two-dimensional infrared vibrational echo spectroscopy. O. Golonzka, M. Khalil, N. Demirdven and A. Tokmakoff, J. Chem. Phys., 115, 10814 (2001).

Correlation effects in the two-dimensional vibrational spectroscopy of coupled vibrations. N. Demirdven, M. Khalil, O. Golonzka and A. Tokmakoff, J. Phys. Chem. A, 105, 8030 (2001).

Polarization-sensitive third-order spectroscopy of coupled vibronic states. O. Golonzka and A. Tokmakoff, J. Chem. Phys., 115, 297(2001).


Signatures of vibrational interactions in coherent two-dimensional infrared spectroscopy. M. Khalil and A. Tokmakoff, Chem. Phys., Chem.l Phys., 266, 213 (2000).

Vibrational anharmonicities revealed by coherent two-dimensional infrared spectroscopy. O. Golonzka, M. Khalil, N. Demirdoven and A. Tokmakoff, Phys. Rev. Lett. 86, 2154 (2000).

Separation of cascaded and direct fifth-order Raman signals using phase-sensitive intrinsic heterodyne detection. O. Golonzka, N. Demirdöven, M. Khalil, and A. Tokmakoff, J. Chem. Phys., 113, 9893(2000).

Polarization-selective femtosecond Raman spectroscopy of isotropic and anisotropic vibrational dynamics in liquids. M. Khalil, Oleg Golonzka, N. Demirdöven, C. J. Fecko, and A. Tokmakoff, Chem. Phys. Lett., 321, 231 (2000).

A phase-sensitive detection method using diffractive optics for polarization-selective femtosecond Raman spectroscopy. M. Khalil, N. Demirdöven, Oleg Golonzka, C.J. Fecko, and A. Tokmakoff, J. Phys. Chem. A, 104, 5711(2000).

Two-dimensional lineshapes derived from coherent third-order nonlinear spectroscopy. Andrei Tokmakoff, J. Phys. Chem. A, 104, 4247 (2000).


Two-dimensional lineshape analysis of photon echo signal. Ko Okumura, Andrei Tokmakoff, and Yoshitaka Tanimura, Chem. Phys. Lett, 314, 488 (1999).

Structural information from two-dimensional fifth order Raman spectroscopy. K. Okumura, A. Tokmakoff, and Y. Tanimura, J. Chem. Phys, 111, 492 (1999).


The intermolecular interaction mechanisms in liquid CS 2 at 299 K and 164 K probed with two-dimensional Raman spectroscopy. A. Tokmakoff, M. J. Lang, X. S. Jordanides and G. R. Fleming, Chem. Phys., 233, 231 (1998).


Del Mar Photonics

Examples of Ultrafast Dynamics Systems supplied by Del Mar Photonics:

Ultrafast Dynamics System

Del Mar Photonics offer complete Ultrafast Dynamics System. Examples of the table schematics is shown on the pictures:

Ultrafast Dynamics Laser System includes Ti:Sapphire Laser, Transient Absorption Spectrometer and Fluorescence Up-Conversion

Ultrafast Dynamics System includes:

Teahupoo Rider High Repetition Rate Amplified Ti:Sapphire Laser
Beacon Up-Conversion Spectrometer
Hatteras Transient Absorption Spectrometer
Femtosecond Harmonics Generator

Teahupoo Rider and other options for Amplified Ti:Sapphire Laser

1. We offer integrated oscillator/amplifier system Teahupoo Rider. Teahupoo Rider is a fully-integrated all-in-one-box system that includes Trestles Finesse oscillator or Buccaneer SHG diode-pumped fiber oscillator, pulse stretcher, regenerative amplifier pumped by multi kHz Nd:YAG pump laser and pulse compressor. Teahupoo Rider has a factory preinstalled repetition rate of 2, 5 or 10kHz and ideal for low cost femtosecond micromachining systems, OPA pumping, ultrafast spectroscopy and variety of applications in life sciences.

One-box system Trestles Finesse that include Trestles mini Ti:Sapphire oscillator and built in DPSS pump laser

When choosing specific Trestles Finesse model please indicate required CW pump power (4W or 6W), Ti:Sapphire pulse duration and required tuning range (or tuning range, where you want to achieve maximum performance)

Tuning range can be customized at the factory by choosing one of standard or custom made optics set. Typical tuning curves for 4W CW pump laser for two standard optics sets are shown in the Trestles Finesse brochure. For example, with 4W CW pump laser and long-wave mirrors set tuning range can be extended up to 940nm. With 6W CW pump laser tuning range can be extended up to 980nm.

2. If you already have a Ti:Sapphire oscillator, we can offer you stand alone Ti:Sapphire amplifier. Two standard models are available: Wedge M multipass or Wedge R regenerative.

Ti:Sapphire oscillator and multipass amplifier

Each amplifier is customized to the customer's amplifier pump laser.

2. Custom Teahupoo Rider systems with a pump laser of your choice are also available. Depending on the required specifications we can recommend a pump laser and make required adjustments for optimum performance.
The following specifications can be achieved:
Repetition rate: single pulses, 10 Hz up to 10kHz
Pulse duration: 100fs, 50fs, 30fs, <30fs
Pulse energy: from 100 mJ per pulse to few mJ per pulse
Tunability: both fixed wavelength and tunable options are available - please indicate required tuning range.


Del Mar Photonics