Del Mar Photonics

Femtosecond Laser Ablation in Developmental Biology

Femtosecond lasers are used for sub-cellular ablation. Several research groups use femtosecond lasers to operate on living zebrafish embryo.

The UCLA Biophysics Neuroimaging Laboratory is committed to developing new microscopy techniques to further the reach of experimental methods in the area of systems neuroscience. The Lab is collaborating to develop next generation multi-photon microscopy systems, with the aim of imaging millimeter volumes of tissue with non-linear enhanced resolution at millisecond time scales. This may improve methods for analysis of in-vivo cortical circuits and classic microcircuit systems via calcium and potentiometric dyes, provide higher throughput for structural imaging, and enable more detailed modeling of systems of nerve cells. Calcium and potentiometric dyes can be used to monitor network activity with single cell and single spike resolution across hundreds of cells. Featured in the laboratory is an ultrafast Ti:Sa oscillator kit from Del Mar Photonics. Output power is typically hundreds of milliwatts. KLM Mode locking is started by voice coil and monitor high bandwidth avalanche photodiode combined with a lock-in amplifier. In this video Adrian Cheng shows his mltiphoton imaging system based on Del Mar Photonics Ti:Sapphire laser and describes his experiments on imaging of neural activity in zebra fish.



 

Engineers and biologists in the Ultrafast Optics and Nanophotonics Laboratory at the University of Alberta have demonstrated the advantages of using femtosecond lasers to manipulate molecules and cellular material inside living cells. In experiments published in Biotechnology and Bioengineering, Vikram Kohli, Abdulhakem Elezzabi, and colleagues used femtosecond laser pulses to perform nanosurgery on living zebrafish embryos to introduce exogenous material into the embryonic cells. Their findings should enhance researchers' ability to noninvasively manipulate molecules in intracellular environments, a critical component in advancing understanding of cellular structure and function.
Several methods have been used for introducing foreign substances into developing embryos. However, microinjection and electroporation, the most commonly used techniques, can be invasive and have some limitations. These limitations are what prompted the researchers to use femtosecond laser pulses to demonstrate the permeabilization of embryos for the delivery of foreign material such as fluorescent probes, quantum dots, and plasmid DNA via transient pores.

 

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Related Publications

An all-optical approach for probing microscopic flows in living embryos. Supatto W, Fraser SE, and Vermot J, Biophysical Journal, in press, (2008). pubmed

in vivo modulation of morphogenetic movements in Drosophila embryos with femtosecond laser pulses. Supatto W, D閎arre D, Moulia B, Brouz閟 E, Martin JL, Farge E, and Beaurepaire E, PNAS, 102(4), 1047-1052 (2005). pubmed ("Research Highlights" in Nature Methods, 2, 155 (2005)).

Quantitative multiphoton imaging and femtosecond pulse-induced ablation to study mechano-sensitive gene expression during early Drosophila embryo development. Supatto W, Paris VII / Institut Curie / Ecole Polytechnique, PhD Thesis (2005).

Tissue deformation modulates Twist expression to determine anterior midgut differentiation in Drosophila embryos. Desprat N, Supatto W, Pouille PA, Beaurepaire E, and Farge E, Developmental Cell, in press (2008).

Femtosecond pulse-induced microprocessing of live Drosophila embryos. Supatto W, D閎arre D, Farge E, and Beaurepaire E, Medical Laser Application, 20(3), special issue on Laser nanoprocessing of biological targets (invited paper), 20(3), 207-216 (2005).

An all-optical approach to modulate and quantitatively analyse embryo morphogenetic movements by using ultrashort laser pulses. Supatto W, D閎arre D, Moulia B, Farge E, and Beaurepaire E. Proc. SPIE - Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues, 6088, 60881D (2006).

in vivo analysis of Drosophila embryo developmental dynamics by femtosecond pulse-induced ablation and multimodal nonlinear microscopy. Supatto W, D閎arre D, Moulia B, Brouz閟 E, Martin JL, Schanne-Klein MC, Farge E, and Beaurepaire E, Proc. SPIE - Multiphoton Microscopy in the Biomedical Sciences V, 5700, 256-264 (2005).

in vivo micro-dissection and live embryo imaging using two-photon microscopy to study Drosophila melanogaster early developement. Supatto W, Brouz閟 E, Farge E, and Beaurepaire E, Proc. SPIE - Femtosecond Laser Applications in Biology, 5463, 13-20 (2004).
 

 V. Kohli and A. Y. Elezzabi, 揕aser surgery of zebrafish (Danio rerio) embryos using femtosecond laser pulses: Optimal parameters for exogenous material delivery, and the laser抯 effect on short- and long-term development " BMC Biotechnology, 8,7 Feb. 2008.

K. J. Chau, Mark Johnson, and A. Y. Elezzabi, 揈lectron-Spin-Dependent Terahertz Light Transport in Spintronic-Plasmonic Media,?Phys. Rev. Lett., 98, 133901-133904 (2007).

S. E. Irvine, P. Dombi, Gy. Farkas, and A. Y. Elezzabi, "Influence of Carrier-Envelope Phase of Few-Cycle Pulses on Ponderomotive Surface-Plasmon Electron Acceleration," Phys. Rev. Lett., 97, 146801-14684 (2006).

K. J. Chau, K. Rieckmann, and A. Y. Elezzabi, 揝ub-Surface Probing of Terahertz Particle Plasmons,?Appl. Phys. Lett., 90, 131114-131117 (2007).

K. J. Chau, C. Baron, and A. Y. Elezzabi, 揑sotropic Photonic Magnetoresistance,? Appl. Phys. Lett., 90, 121122 (2007).

M. C. Quong, and A. Y. Elezzabi, 揙ffset-Apertured Near-Field Scanning Optical Microscope Probes,?Opt. Express 15, 10408-10420, (2007).

K. J. Chau, M. C. Quong, and A. Y. Elezzabi, 揟erahertz Time-Domain Investigation of Axial Optical Activity from a Sub-Wavelength Helix,?Opt. Express 15, 3557-3567 (2007).

Vikram Kohli, Vanesa Robles , M. Leonor Cancela , Jason P. Acker , Andrew J. Waskiewicz , and Abdulhakem Y. Elezzabi, 揂n Alternative Method for Delivering Exogenous Material into Developing Zebrafish Embryos,?Biotechnol and Bioeng., 98, 1230-1241 (2007).

K. J. Chau, K. Rieckmann, and A. Y. Elezzabi, 揗etallic Phase Transition Investigated via THz Time-Domain Spectroscopy,?Appl. Phys. Lett., 90, 041920 (2007).

G. D. Dice and A. Y. Elezzabi, 揜andom Lasing from a Nanoparticle-Based Metal朌ielectric朌ye Medium,?J. Opt. A: Pure Appl. Opt., 9 186-193, (2007).

S. E. Irvine and A. Y. Elezzabi, "Ultracompact 180?Magnetic Spectrometer for Intermediate Energy Electron Measurement," Meas. Sci. Tech., 17, 2455-2460, (2006).

K. J. Chau and A. Y. Elezzabi, 揚hotonic Anisotropic Magnetoresistance in Dense Co Particle Ensembles,?Phys. Rev. Lett., 96, 033903-033906, (2006).

K. J. Chau and A. Y. Elezzabi, 揈ffect of Interface Resistance on Terahertz Pulses in Bimetallic Microparticles,?Phys. Rev. B 73, 085419-085425 (2006).

S. E. Irvine and A. Y. Elezzabi, 揝urface-Plasmon-Based Electron Acceleration,? Phys. Rev. A 73, 013815-013523 (2006).

S. E. Irvine and A. Y. Elezzabi, 揊emtosecond Electron Pulse Gating Using Surface Plasmons,?Opt. Express 4115-4127, (2006).

K. J. Chau, G. D. Dice, and A. Y. Elezzabi, 揅oherent Plasmonic Enhanced Terahertz Transmission through Random Metallic Media,?Phys. Rev. Lett., 94, 173904-173908 (2005).

G. D. Dice, S. Mujumdar , and A. Y. Elezzabi, 揚lasmonically Enhanced Diffusive and Subdiffusive Metal Nanoparticle-Dye Random Laser,?Appl. Phys. Lett., 86, 131105-131105, (2005).

K. J. Chau and A. Y. Elezzabi, 揟erahertz Transmission Through Ensembles of Sub-wavelength Size Metallic Particles,?Phys. Rev. B 72, 075110 (2005).

S. E. Irvine and A. Y. Elezzabi, 揚onderomotive Electron Acceleration Using Surface Plasmon Waves Excited with Femtosecond Laser Pulses,?Appl. Phys. Lett., 86, 264102-264105, (2005).

V. Kohli, A. Y. Elezzabi, and J. P. Acker, 揅ell Nanosurgery Using Ultrashort (Femtosecond) Laser Pulses: Applications to Membrane Surgery and Cell Isolation? Laser Surg. Med., 37, 227-230, (2005).

V. Kohli, J. P. Acker, and A. Y. Elezzabi 揜eversible Permeabilization Using High-Intensity Femtosecond Laser Pulses: Applications to Biopreservation,? Biotech. and Bioeng., 92, 889-899, (2005).

K. J. Chau, A. L. Dechant, and A. Y. Elezzabi, 揌igh-Bandwidth Terahertz Radiation from Ponderomotively Accelerated Carriers Using Bessel-Gauss Femtosecond Pulses,?Appl. Phys. Lett., 86, 064106- 064109, (2005).

L. Dechant, S. K. Dew, S. E. Irvine, and A. Y. Elezzabi, 揌igh-Transmission Solid-Immersion Apertured Optical Probes for Near-Field Scanning Optical Microscopy,?Appl. Phys. Lett., 86, 013102-013105, (2005).

S. E. Irvine , A. L. Dechant, and A. Y. Elezzabi, 揋eneration of 0.4-keV Femtosecond Electron Pulses Using Impulsively Excited Surface Plasmons,?Phys. Rev. Lett., 93, 184801-184804, (2004).

S. Mujumdar, K. J. Chau, and A. Y. Elezzabi, 揈xperimental and Numerical Investigation of Terahertz Transmission through Strongly Scattering Sub-wavelength Size Spheres,?Appl. Phys. Lett., 85, 6284-6286, (2004).

S. Mujumdar, G. Dice, and A. Y. Elezzabi, 揊ew Cycle Pulse Propagation in Multiple Scattering Media,?Opt. Comm., 247, 19-27, (2005).

L. Dechant and A. Y. Elezzabi, 揊emtosecond Optical Pulse Propagation in Subwavelength Metallic Slits,?Appl. Phys. Lett., 84, 4678- 4678, (2004).

K. J. Chau and A. Y. Elezzabi, 揟wo-Dimensional Drift-Diffusion Analysis of Magnetic Field Enhanced THz Emission from Semiconductor Surfaces,?Opt. Comm., 242, 295-304, (2004).

K. J. Chau, S. E. Irvine, and A. Y. Elezzabi, 揂 Gigahertz Surface Magneto-Plasmon Optical Modulator,?IEEE J. Quantum Electron., vol. 40, 571-579, (2004).






J. F. Holzman and A. Y. Elezzabi, ?Two-Photon Photoconductive Terahertz Generation in ZnSe,?Appl. Phys. Lett., 83, 2967-2969 (2003).


J. F. Holzman and A. Y. Elezzabi, "Dispersion-Free High-Speed Beam Chopper for Ultrafast Pulsed Laser Applications," Meas. Sci. Tech. 14, pp. N41-N44 (2003).


S. E. Irvine and A. Y. Elezzabi, "A Miniature Broadband Bismuth-Substituted Yttrium Iron Garnet Magneto-Optic Modulator," Journal of Physics D: Applied Physics, Special Issue: The subject interface between magnetism and photonics, vol. 36, pp. 2218-2221 (2003).


S. E. Irvine and A. Y. Elezzabi, "Wideband Magneto-Optic Modulation in a Bismuth-Substituted Yttrium Iron Garnet Waveguide," Optics Communications, vol. 220, pp. 325-329 (2003).


A. Y. Elezzabi and S. E. Irvine, "Parametrically Driven First-Order Suhl Instability and Nonlinearitites in Bismuth-Substituted Yttrium Iron Garnet Films," Appl. Phys. Lett., vol. 82, pp. 2464-2466 (2003).


A. Y. Elezzabi and J. F. Holzman, "Photoconductive Generation and Detection of Guided-Wave and Free-Space Terahertz Waveforms," IEICE Transactions on Electronics E86C, pp. 1218-1225 (2003). (Invited)


J. F. Holzman, S. E. Irvine, F. E. Vermeulen, A. Y. Elezzabi, "Free-Space Detection of Terahertz Radiaton Using Crystalline and Polycrystalline ZnSe Electro-optic Sensors," Appl. Phys. Lett., 81, 2294 (2002).



S. E. Irvine and A. Y. Elezzabi, 揗odeling of High-Speed Magneto-Optic Beam Deflection,?IEEE Jour. Quantum Elec., 38, 1428, (2002).



S. E. Irvine and A. Y. Elezzabi, 揗ulti-Gigahertz Guided Wave Magneto-Optic Modulator,?IEEE Photonics Technol. Lett., 14, 798, (2002).



M. D. Cummings, J. F. Holzman, and A. Y. Elezzabi, 揅arrier Transport Dynamics in an Edge-Illuminated Photoconductive Switch,?J. Vac. Sci. Technol., A20, 1057, (2002).


J. F. Holzman, F. E. Vermeulen, and A. Y. Elezzabi, 揋eneration of 1.2 ps Electrical Pulses Through Parallel-Gating in Ultrathin Silicon Photoconductive Switches,?Appl. Phys. Lett., 79, 4249-4252, (2001).



M. D. Cummings and A. Y. Elezzabi, 揢ltrafast Impulsive Excitation of Coherent Longitudinal Acoustic Phonon Oscillations in Highly Photoexcited InSb,?Appl. Phys. Lett., 79, 770-772, (2001).

 M. D. Cummings, J. F. Holzman, and A. Y. Elezzabi, 揊emtosecond Carrier Dynamics in an Asymmetrically Excited GaAs Photoconductive Switch,?Appl. Phys. Lett.,78, 3535-3537, (2001).

 J. F. Holzman, F. E. Vermeulen, and A. Y. Elezzabi, 揊rozen Wave Generation of Bandwidth-Tunable Two-Cycle THz Radiation,?J. Opt. Soc. Am. B, 17, 1457-1463, (2000).

 J. F. Holzman, F. E. Vermeulen, B. W. Arnold, and A. Y. Elezzabi, 揚hotoconductive Gating of Picosecond Electrical Pulses on Thinned Si-Substrates,? Electronics Lett., 36, 1225-1226, (2000).

 J. F. Holzman, F. E. Vermeulen, and A. Y. Elezzabi, 揜ecombination-Independent Photogeneration of Ultrashort Electrical Pulses,? Appl. Phys. Lett., 76, 134-136, (2000).

 J. F. Holzman, F. E. Vermeulen, and A. Y. Elezzabi, 揢ltrafast Photoconductive Self-Switching of Subpicosecond Electrical Pulses,?IEEE J. Quantum Electron, 36, 130-136, (2000).

 A. Y. Elezzabi, J. F. Holzman, J. Sit, K. Robbie, and M. J. Brett, 揟hin Film Vertical Diffraction Gratings Fabricated Using Glancing Angle Deposition,? Electronics Letters, 35, 491-493, (1999).

 J. F. Holzman, F. E. Vermeulen, and A. Y. Elezzabi, 揢ltrafast All-Optical Modualtion of Infrared Radiation Via Metal-Semiconductor Waveguide Structures,? IEEE J. Quantum Electron, 35, 583-589, (1999).

 G. M. Steeves, A. Y. Elezzabi, R. Teshima, R. A. Said, and M. R. Freeman, 揅ircuit Analysis of an Ultrafast Junction Mixing Scanning Tunneling Microscope,?IEEE J. Quantum Electron., 34, 1415-1418, (1998).

 G. M. Steeves, A. Y. Elezzabi, and M. R. Freeman, 揘anometer-Scale Imaging with an Ultrafast Scanning Tunneling Microscope,?Appl. Phys. Lett. 72, 504-506 (1998).

 G. M. Steeves, A. Y. Elezzabi, and M. R. Freeman, 揂dvances in Picosecond Scanning Tunneling Microscopy Via Junction Mixing,?Appl. Phys. Lett., 70, 1909-1911, (1997).

 M. R. Freeman, A. Y. Elezzabi, and J. A. H. Stotz, 揅urrent Dependence of the Magnetization Rise Time in Thin Film Heads? J. Appl. Phys., 81, 4516-4518, (1997).

 M. R. Freeman, A. Y. Elezzabi, G. M. Steeves, G. Nunes, Jr., 揢ltrafast Time-resolution in Scanning Tunneling Microscopy,?Surface Sci., 386, 290-900, (1997).

 A. Y. Elezzabi and M. R. Freeman, 揢ltrafast Magneto-Optic Sampling of Picosecond Current Pulses,?Appl. Phys. Lett., 68, 3546-3548, (1996).

 A. Y. Elezzabi, M. R. Freeman, and Mark Johnson, 揇irect Measurement of the Conduction Electron Spin-Lattice Relaxation Time T1 in Gold,?Phys. Rev. Lett., 77, 3220-3224, (1996).

 A. Y. Elezzabi, M. K. Y. Hughes, J. Meyer, and S. R. Johnson, 揢ltrafast Measurement of Nonequilibrium Carrier Lifetime in In0.85Ga0.15As/GaAs Relaxed Superlattice Structure,?Opt. Lett., 20, 587-589, (1995).

 J. Meyer, A. Y. Elezzabi, and M. K. Y. Hughes, 揑nfrared Absorption and Momentum Relaxation of Free Carriers in Silicon Generated by Subpicosecond Above Band Gap Radiation,?IEEE J. Quantum Electron., 31, 729-734, (1995).

 J. Meyer, A.Y. Elezzabi, and M. K. Y. Hughes, 揂n Investigation of Ultrafast Plasma Dynamics in a GaAs Infrared Reflection Switch,?IEEE J. Quantum Electron., 31, 1292-1301, (1995).

 A. Y. Elezzabi, J. Meyer, and M. K. Y. Hughes, ?00 fs 10.6 mm Infrared Pulse Generation with Radiation-Damaged GaAs Reflection Switch,?Appl. Phys. Lett., 66, 402-404, (1995).

 H. Houtman, A. Cheuck, A. Y. Elezzabi, J. E. Ford, M. Laberge, W. Liese, J. Meyer, G. C. Stuart, and Y. Zhu, 揌igh-Speed Circuits for TE Discharge Lasers and High Voltage Applications,?Rev. Sci. Instrum., 64, 839-853, (1994).

 A. Y. Elezzabi, J. Meyer, M. K. Y. Hughes, and S. R. Johnson, 揋eneration of 1-ps Infrared Pulses at 10.6 um by Use of Low-Temperature-Grown GaAs as an Optical Semiconductor Switch,?Opt. Lett., 19, 898-900, (1994).

 . Y. Elezzabi and J. Meyer, 揂ll-Optical Time-Division Demultiplexer Using Semiconductor Switching,?Appl. Opt., 33, 3635-3641, (1994).

 Y. Elezzabi, H. Houtman, and J. Meyer, 揟ime-Resolved Impact Ionization in ZnSe High-Voltage Switches,?IEEE Trans. on Plasma Science, 22, 1043-1048, (1994).

 Y. Elezzabi and J. Meyer, 揝imulation of the Generation of Ultrafast Mid-Infrared Laser Pulses,?IEEE J. Quantum Electron., 28, 1830-1834, (1992).

 J. Meyer and A. Y. Elezzabi, 揝ubpicosecond Reflection Switching of 10 um Radiation Using Semiconductor Surfaces,?Appl. Phys. Lett., 58, 1940-1943, (1991).

 J. Meyer and A. Y. Elezzabi, 揈xperimental Study of the Electron Density and Discharge Dynamics in a XeCl Excimer Laser ,?J. Appl. Phys., 68, 3838-3843, (1990).

Other Publications

A. Y. Elezzabi, K. J. Chau, C. A. Baron, and Mark Johnson, 揇iscovering Spinplasmonics,?Proc. SPIE Int. Soc. Opt. Eng., (Invited), (in print).

Vikram Kohli and A. Y. Elezzabi, 揊emtosecond Laser Pulse Surgery and Transfection in Embryos,?Proc. SPIE Int. Soc. Opt. Eng., (Invited), (in print).

K. J. Chau, M. C. Quong, and A. Y. Elezzabi, 揢ltrafast Terahertz Electric Field Polarization Dynamics in Metallic Mesostructures, Proc. SPIE Int. Soc. Opt. Eng., 6471, 64710P (2007), (Invited)

C. A. Baron, K. J. Chau, and A. Y. Elezzabi, 揟erahertz Isotropic Photonic Magnetoresistance,?Proc. SPIE Int. Soc. Opt. Eng., 6471, 64710N (2007) (Invited).

A. Y. Elezzabi, 揝pinplasmonics: A New Route for Active Plasmonics,?Proc. SPIE Int. Soc. Opt. Eng. 6441, 6641-57 (2007), (Invited)

K. J. Chau and A. Y. Elezzabi, 揈xtraordinary Single Cycle Terahertz Transmission through Ensembles of Sub-Wavelength Size Metal Particles,?Proc. SPIE Int. Soc. Opt. Eng., 6118, 61180L-1 (2006), (Invited).

K. J. Chau and A. Y. Elezzabi, 揚hotonic Anisotropic Magnetoresistance in Sub-Wavelength Size Co Particles,?Proc. SPIE Int. Soc. Opt. Eng., 6118, 61180M-1 (2006), (Invited).

Kenneth J. Chau and A. Y. Elezzabi, 揂 Two-Dimensional Drift-Diffusion Model of THz Emission from n-GaAs and InAs Surfaces in a Magnetic Field?Proc. SPIE Int. Soc. Opt. Eng., 5725, 61 (2005), (Invited).

A. Y. Elezzabi and J. F. Holzman, "Photoconductive Generation and Detection of Guided-Wave and Free-Space Terahertz Waveforms," IEICE Transactions on Electronics E86C, pp. 1218-1225, 2003. (Invited)

J. F. Holzman, M. D. Cummings, and A. Y. Elezzabi, "Terahertz Photonics: Ultrafast Physics and Applications," Proc. SPIE, 4833, Applications of Photonic Technology 5, 85-96, (2003), (Invited).

Vikram Kohli and A. Y. Elezzabi, 揚art I: Embryonic Surgery Using Femtosecond Laser Pulses for the Delivery of Exogenous Materials and the Analysis of Gene Expression,?Proc. SPIE, 2008 (accepted and in print).

Vikram Kohli and A. Y. Elezzabi, 揚art II: Morphological Analysis of Embryonic Development Following Femtosecond Laser Manipulation,?Proc. SPIE, 2008 (accepted and in print).

C. A. Baron and A. Y. Elezzabi, 揟ime- and Angular-Resolved Terahertz Spectroscopy?Proc. SPIE, 2008 (accepted and in print).

Vikram Kohli, Deli Yu, and Abulhakem Y. Elezzabi, ?Laser-Assisted Ablation of Corneal-Like Material Using Focused Femtosecond Laser Pulses,?Proc. SPIE, 6460, 6460-D, 2007.

K. J. Chau, Mark Johnson, and A. Y. Elezzabi, 揗erging Spintronics and Plasmonics,?Conference on Lasers and Electro-Optics Tech. (APS, IEEE, OSA), Baltimore , Maryland , May 6-11, 2007, (Postdeadline Digest-CPDA5).

K. J. Chau and A. Y. Elezzabi, THz Phase Transition Spectroscopy of Metals, Conference on Lasers and Electro-Optics Tech. Digest (APS, IEEE, OSA), JFB1, Baltimore, Maryland, May 6-11, 2007.

Michael C. Quong and Abdulhakem Y. Elezzabi, 揂n Offset-Apertured Probe: a Hybrid Apertured and Scattering-Type Near-Field Scanning Optical Probe,? Conference on Lasers and Electro-Optics Tech. Digest (APS, IEEE, OSA), JThD58, Baltimore , Maryland , May 6-11, 2007.

C. A. Baron, K. J. Chau, and A. Y. Elezzabi, 揑sotropic Photonic Magnetoresistance: A New Phenomenon at Terahertz Frequencies,?Conference on Lasers and Electro-Optics Tech. Digest (APS, IEEE, OSA), JFB3, Baltimore , Maryland , May 6-11, 2007.

K. J. Chau and A. Y. Elezzabi, 揑nvestigations on the Origin of the Terahertz Transmission through Random Metallic Media,?Conference on Lasers and Electro-Optics Tech. Digest (APS, IEEE, OSA), JtuD23, Long Beach , CA , May 21-26, 2006.

G. D. Dice, K. J. Chau, and A. Y. Elezzabi, 揝urface Plasmon Enhanced Metal Nanoparticle-Dye Random Laser,?Conference on Lasers and Electro-Optics Tech. Digest (APS, IEEE, OSA, 2006), CMFF6, Long Beach, CA, May 21-26, 2006.

K. J. Chau and A. Y. Elezzabi, 揅ontact Resistance Dynamics at Bimetallic Interfaces Investigated by Ultrafast Terahertz Surface Plasmon-Mediated Transmission Spectroscopy,?Proc. SPIE, 6118, 61184- (1-9), 2006.

K. J. Chau and A. Y. Elezzabi, 揘ear-Field Mediated Terahertz Transmission through Random Media,?Conference on Lasers and Electro-Optics Tech. Digest (APS, IEEE, OSA), CMI5, Long Beach , CA , May 21-26, 2006.

G. D. Dice, K. J. Chau, and A. Y. Elezzabi, 揝urface Plasmon Enhanced Metal Nanoparticle-Dye Random Laser,?Conference on Lasers and Electro-Optics Tech. Digest (APS, IEEE, OSA), Long Beach, CA, May 21-26, 2006.

Vikram Kohli, Jason P. Acker, and Abdulhakem Y. Elezzabi, 揚ermeabilization and Cell Surgery Using Femtosecond Laser Pulses: an Emerging Tool for Cellular Manipulation,?Optical Interactions with Tissue and Cells XVII, Proc. SPIE 6084, 608414 (2006).

S. E. Irvine and A. Y. Elezzabi, 揋eneration of 2 keV, 30 fs Electron Pulses via Surface Plasmon Waves,?Conference on Lasers and Electro-Optics Tech. Digest (APS, IEEE, OSA) Baltimore, Maryland, May 22-27, 2005.

K. J. Chau and A. Y. Elezzabi, 揃roadband Terahertz Pulse Propagation in Strongly Scattering Random Media,?Conference on Lasers and Electro-Optics Tech. Digest (APS, IEEE, OSA) Baltimore , Maryland , May 22-27, 2005.

K.J. Chau, S. Mujumdar , and A.Y. Elezzabi, 揟erahertz Propagation in Non-Homogeneous Highly Scattering Media,?Proc. SPIE, 5727, 177-185 (2005).

K. J. Chau and A. Y. Elezzabi, 揢ltra-wide Bandwidth THz Emission from Semiconductor Irradiated with Intense Radially Polarized, Bessel-Gauss Pulses,? Ultrafast Phenomena XIV, Eds. T. Kobayashi, T. Okada, T. Kobayashi, Keith A. Nelson, and S. DeSilvestri, Springer Series in Chemical Physics 667-669, (2004).

S. E. Irvine and A. Y. Elezzabi, 揝urface Plasmon Assisted 26, 0.4 keV Electron Pulse Generation,?Ultrafast Phenomena XIV, Eds. T. Kobayashi, T. Okada, T. Kobayashi, Keith A. Nelson, and S. DeSilvestri, Springer Series in Chemical Physics 708-710, (2004).

A. L. Dechant and A. Y. Elezzabi, 揚lasmon Enhanced Ultrafast Optical Transmission in Metallic Nano-Arrays,?Ultrafast Phenomena XIV, Eds. T. Kobayashi, T. Okada, T. Kobayashi, Keith A. Nelson, and S. DeSilvestri, Springer Series in Chemical Physics 658-660, (2004).

K. J. Chau, S. E. Irvine, and A. Y. Elezzabi, 揌igh-Speed Surface Magneto-Plasmon Reflectivity Modulator,?OSA Conference on Lasers and Electro-Optics Tech. Digest (APS, IEEE, OSA), San Francisco, CA, May 16-21, (2004)

S. E. Irvine and A. Y. Elezzabi, "Polarization-Selective Optical Beam Deflection Using Magnetically Activated Bi-YIG Films,?Proc. of SPIE, 5260, 585-590 (2003).

S. E. Irvine and A. Y. Elezzabi, "Parametric Excitation of Spin Waves in Bismuth-substituted Yttrium Iron Garnet Films Using the First-Order Suhl Instability," Proc. Int. Conf. on MEMS, NANO, and Smart Systems, Banff, AB, 148-152, 2003.

S. E. Irvine and A. Y. Elezzabi, "Broadband Optical Modulation Using Magneto-Optic Bi-YIG Thin Films," Proc. of SPIE, 5260, 580-584 (2003).

M. D. Cummings and A. Y. Elezzabi, 揚hoto-excitation of Coherent Acoustic Phonons in InSb,?Ultrafast Phenomena XIII, Eds. R. D. Miller, M. M. Murnane, N. F. Scherer, and A. M. Weiner, Springer Series in Chemical Physics, 383-386, (2002).

M. D. Cummings and A. Y. Elezzabi, 揚hoto-excitation of Coherent Acoustic Phonons in InSb,?Ultrafast Phenomena XIII, edited by R. D. Miller, M. M. Murnane, N. F. Scherer, and A. M. Weiner, Springer Series in Chemical Physics, 383, (2002).

J. F. Holzman, F. E. Vermeulen, and A. Y. Elezzabi, 揊rozen Wave Sources for Multi-Cycle THz Generation,?Proc. of SPIE, 4111, 100-107, (2000).

J. F. Holzman, F. E. Vermeulen, and A. Y. Elezzabi, 揚hotoconductive Generation of 2-ps Electrical Pulses with Semi-insulating GaAs,?Proc. of SPIE, 4111, 108-115, (2000).

G. D. Jones and A. Y. Elezzabi, 揢ltrafast Broadband Tunable-bandwidth Magneto-Optic Modulator,?Proc. of SPIE, 4111, 145-152, (1999).

J. F. Holzman, F. E. Vermeulen, and A. Y. Elezzabi, 揋uided-Wave Metal-Semiconductor Switch for Modulation of 10.6 mm Radiation? Proc. of SPIE, 3795, 137-144, (1999).

 J. F. Holzman, A. Y. Elezzabi, F. E. Vermeulen, and C. E. Capjack, 揝low Wave Guiding Structures for Phase Matching in High Harmonic Generation Processes,?Proc. of SPIE, 3771, 22-29, (1999).
 

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